Senior Scientist – Cell Line Biology and Development – Boston, MA

Senior Scientist – Cell Line Biology and Development

UCB Biosciences

Bedford, MA (Boston)

Help us transform patients’ lives.

At UCB, we put our heart, soul and skills into making a difference for people living with severe disease. Working together to push the boundaries, we blend the best of our talents to unlock innovation. Will you join us in our pioneering adventure?

Job Summary

  • The Vector Biology and Discovery team is seeking a talented cell/molecular biologist with expertise in cell line development and characterization. He/she will collaborate with global project teams to advance therapeutic AAV projects and producer cell line platforms.

Major Accountabilities

  • Apply hands-on expertise with molecular and cellular techniques to investigate and characterize producer cell lines
  • Utilize technologies including gene editing, silencing, and overexpression to improve cell lines for production of therapeutic AAV vectors
  • Collaborate with process development and vector engineering teams on research studies
  • Provide scientific insight and guidance in projects/platforms, including strong scientific thinking and hypothesis development
  • Drive projects locally with clear scientific direction and experimental design, including providing scientific supervision to junior scientists
  • Prepare, analyze, and present high quality data
  • Prepare and review technical reports and write research operating protocols
  • Communicate and work effectively as a member of a multidisciplinary team.

Education and Qualification

  • PhD in virology, molecular biology, genetics, biochemical/chemical engineering or a related field with 3-5 years of experience. Industry experience highly preferred.
  • Hands-on experience in drug discovery research, including expertise in cell culture systems to produce viral vectors or biologics. Experience with AAV for gene therapy is preferred.
  • Significant expertise with NGS techniques and analysis, CRISPR/Cas9 gene editing/silencing, siRNA knockdown, and proteomics.
  • Experience with high-throughput screening, producer cell lines, high-throughput or disposable bioreactors, and culture media optimization is preferred.
  • Proficiency with mammalian cell culture, cell-based assays, and molecular techniques (cloning, immunoassays, RT-qPCR, etc.).


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