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Posted Job Title
Senior Research Investigator
Job Profile Title
Research Investigator, Senior
Job Description Summary
The Prosser Lab is developing novel therapies for rare, genetic Epilepsies and Neuro-Developmental Disorders (ENDD therapeutics team). It is pursuing antisense oligonucleotide (ASO) and small molecule-based strategies to correct for gene deficiencies that lead to pediatric encephalopathies. The Prosser lab collaborates with other ENDD teams, including the lab of Dr. Elizabeth Heller, to study the mechanisms by which epigenetic remodeling regulates gene function and is pursuing the use of epigenetic editing tools, such as CRISPR/dCas9-fusion proteins, for the correction of such gene deficiencies. While these approaches hold potential to treat a variety of neurodevelopmental disorders, our current focus is encephalopathy caused by mutations in STXBP1 and SYNGAP1.
We seek to hire a Senior Research Investigator for our collaborative team to develop new treatments for pediatric brain disease. The primary appointment will be in Physiology, while working in partnership with the Penn Epigenetics Institute and Dr. Heller. The team collaborates closely with the pharmaceutical industry and other labs throughout campus.
Design and perform cell and molecular biology experiments
Process, analyze, and interpret next-generation sequencing (NGS) data and large-scale biomedical data
Write and maintain technical protocols
Contribute to manuscript writing and grant proposal submissions
Coordinate and interface with collaborators at Penn and in industry
Purchase supplies and reagents
Present research results at meetings and seminars
Other duties as assigned
Ph.D. in cell and molecular biology, biochemistry or related field. 5-7 years of relevant postdoctoral experience. Expertise in molecular biology is required; knowledge of bioinformatics, RNA biology, neurobiology, chromatin biology, and antisense technologies are preferred. Expertise demonstrated by published papers in peer reviewed scientific journals is required as are excellent written and oral communication skills.
This position is contingent on grant funding.
Job Location – City, State
Department / School
Perelman School of Medicine
$35,568.00 – $204,000.00
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